Introducing Top 10 health tech unicorns

For the coming newsletters, I will shed a light on health tech unicorns.

Here are the top 10 in the field of health, according to CB Insights.

This week, let’s take a brief look at Samumed, which has a top valuation in health sector.

Samumed Launches Phase 3 Lorecivivint (SM04690) Clinical Program ...

valuation$12B
founded in2008
arearegenerative medicine

Samumed’s pipeline

source: samumed

What is attracting attention/money?

  • anti-aging program

The company has several pipelines that aim to reverse aging.

The two most advanced pipelines are knee arthritis and AGA, a common form of hair loss.

In 2017, the company also announced a collaboration with L’Oreal to develop compound SM05253 for Anti-wrinkle skin care applications. However, they seem not to have announced any updates on this.

“People label us as an anti-aging company sometimes, but we consider our platform to be ‘de-aging.’…That is, to actually restore youth, to go back to peak health.” 

Samumed CEO Osman Kibar for FierceBiotech (2019 Aug)

What technology do they use?

Samumed looks at regulating adult stem cells.

For tissue health, says Samumed, regulating the self-renewal and differentiation of adult stem cells is crucial. The failure can result in disease.

One of the primary signaling pathways to regulate is the Wnt pathway. Samumed thinks that if they can modulate the Wnt pathway, they can recover and restore the health of diseased tissues.

Their pipelines include knee arthritis, AGA(hair loss), as well as Alzheimer’s disease and oncology. I will follow up with their recent development, and whether they are living up to the hype.

In the coming weeks, I will also shed light on other health-tech unicorns on the list.

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Update on COVID-19 treatment + vaccines

Here’s a wrap up on this week’s COVID-19 related news, with a focus on treatment and vaccines.


June 1st

Eli Lilly begins a human study of a potential COVID-19 antibody treatment

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  • What’s the significance?

 This could be the first potential new medicine specifically designed to attack SARS-CoV-2, the virus that causes COVID-19.

  • How does it work?

LY-CoV555 is a potent, neutralizing antibody against the spike protein of SARS-CoV-2. It is designed to block the virus to enter human cells, potentially preventing and treating COVID-19. 

Lilly scientists developed the antibody in three months after the antibody was identified from one of the earliest U.S. patients’ blood sample. 

  • What are other candidates?
nametypecompanyexisting/new
Remdesivirantiviral drugGilead Sciencesexisting
Favipiravirantiviral drugFuji filmexisting
hydroxychloroquineanti-malariaSanofiexisting
tocilizumabimmunosuppressive drugChugaiexisting
antibody cocktail therapyRegeneronnew
VIR-7831 and VIR-7832
antibody therapyVir, GSKnew

June 3rd

White House selects five coronavirus vaccine candidates, the New York Times reports

*There has been no official announcement from the White House. NYT address the source as “senior officials.”

  • Which are reported to be finalists?
companycurrent stateaim to start inaim to produce
ModernaPhase 2the end of 2020 – early 20211b dose/year
Oxford University/ AstraZenecaPhase2b,3September 20201b/year
J&Jpre-clinical20211b/year
Merckpre-clinical
PfizerPhase1,2the end of 2020

White House is expected to make an official announcement in the next few weeks.

  • What are the most advanced vaccine candidates?

There are 10 candidates currently under clinical trials.

companycountryaim to start inaim to produce
Oxford Uni/ AstraZenecaUKSept. 20201b/year
CanSinoChina
ModernaUSthe end of 2020- early 20211b/year
Sinopharm/ WuhanChina
Sinopharm/BeijingChina
SinovacChina100m/year
NovavaxUS100m/year
BioNTech/PfizerGermany/UShundreds of millions by 2021
Chinese Academy of
Medical Sciences
China
InovioUSthe end of 2020million by 2020

There are three approaches toward containing COVID-19:

  1. Use existing drugs for the treatment
  2. Find new drugs
  3. develop vaccines

For the past few weeks, I have been reporting on vaccines, especially the new technology called mRNA.

Edited by Jun Morikawa, Design by Tomoka Kunihiro

I would also like to dig deeper into the drug discovery side. Let me follow up in the coming newsletters.

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